Patients

BLOOD COMPONENT THERAPY

Whole Blood : Whole blood contains red cells, white cells, and platelets (~45% of volume) suspended in plasma (~55% of volume).

Red cells : Red cells, or erythrocytes, carry oxygen from the lungs to body’s tissue and take carbon dioxide back to lungs to be exhaled.
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Platelets : Platelets, or thrombocytes, are small, colourless cell fragments in the blood whose main function is to interact with clotting proteins to stop or prevent bleeding.
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Plasma : Plasma is a fluid, composed of about 92% water, 7% vital proteins such as albumin, gamma globulin, anti- haemophilic factor, and other clotting factors, and 1% mineral salts, sugars, fats, hormones and vitamins.
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Cryoprecipitated AHF : Cryoprecipitated Anti- haemophilic Factor (Cryo) is a portion of plasma rich in clotting factors, including Factor VIII and fibrinogen. It is prepared by freezing and then slowly thawing the frozen plasma

Transfusable Blood Components Summary

Whole Blood

Red Blood Cells

Platelets

Plasma

Cryoprecipitated AHF

SHELF LIFE

21 / 35 Days*

Up to 42 Days*

5 Days

1 Year

1 Year

STORAGE CONDITIONS

Refrigerated

Refrigerated

Room temperature with constant agitation to prevent clumping

Frozen

Frozen

INDICATIONS

  • Trauma
  • Surgery
  • Trauma
  • Surgery
  • Anemia
  • Any blood loss
  • Blood disorders, such as sickle cell
  • Cancer treatments
  • Organ transplants
  • Surgery
  • Dengue fever
  • Malaria
  • Burn patients
  • Shock
  • Bleeding disorders
  • Hemophilia
  • Von Willebrand disease
  • Rich source of Fibrinogen

NOT INDICATED FOR

  • Deficiency anemia treatable pharmaco- logically
  • Coagulation factor deficiencies
  • Deficiency anemia treatable pharmaco- logically
  • Coagulation factor deficiencies
  • Plasma coagulation factor deficit, TTP, HUS, ITP except in life saving situations
  • Conditions responsive to volume replacement
  • Conditions not deficient in contained factors

DOSAGE

1 unit RBC increases Hct 3%

increases Hb by 1gm% (approx.)

Increases platelet count by 5000 to 10000µ/L per unit of RDP

Increases platelet count by 30 to 60000µ/L per unit of SDP

10 -15 ml/kg increases factor levels 20 - 30%

Factor VIII - 1 unit/kg increases level by 2%

SPECIAL CONSIDERATION

Must be ABO & Rh compatible and X- match compatible

Must be ABO & Rh compatible and X- match compatible

Preferably group compatible. However, non group specific platelets can be given

ABO compatible only, No Rh compatibility or X- match required

No ABO, Rh or X- match required

  • Shelf life of whole blood and red cells varies based on the type anticoagulant used.

Blood groups

Blood groups are the results of antigens (large protein molecules) which are present on red blood cells. Primarily there are two such antigens A & B which decide our ABO blood group.

ABO blood groups were first discovered by Dr. Landsteiner in 1900. Rh antigen was discovered forty years later again by Dr. Landsteiner and Weiner. Rh gets its name from Rhesus monkey, in whom it was discovered. On the basis of these antigens or in combination the blood groups are decided as given below.

Antigen A & B

Antigen Rh (Yes/No)

Blood Group

Can Donate Blood to

Can receive Blood from

A

Yes

A+

A+, AB+

A+, A-, O+, O-

B

Yes

B+

B+, AB+

B+, B-, O+, O-

A & B

Yes

AB+

AB+

A+, B+, AB+, O+, O-, A-, B-, AB- (Universal recipients)

Neither A nor B

Yes

O+

A+, AB+, B+, O+

O+, O-

A

No

A-

A+, AB+, A-, AB-

A-, O-

B

No

B-

B+, AB+, B-, AB-

B-, O-

A & B

No

AB-

AB-

A-, B-, AB-, O-

Neither A nor B

No

O-

A+, B+, AB+, O+, A-, B-, AB-, O- (Universal Donor)

Only O-